Talk:Modafinil

Modafinil is currently a Biology and medicine good article nominee. Nominated by Maxim Masiutin (talk) at 21:24, 23 December 2024 (UTC)

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Short description: Eugeroic medication

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Modafinil was nominated as a Natural sciences good article, but it did not meet the good article criteria at the time (February 13, 2024, reviewed version). There are suggestions on the review page for improving the article. If you can improve it, please do; it may then be renominated.

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Drug Tolerance

The section on drug tolerance contradicts itself. The first para states that "Extensive clinical research has not demonstrated drug tolerance...."; the next four paras describe development of tolerance! The first para references different cites from the remainder of the section. One would need to check these references rather carefully to see what confidence can be placed in this opening statement, and whether it needs to be qualified. I believe modafinil has a much lower risk of developing tolerance in short-term or occasional use than the amphetamines, but I would be very surprised if it were shown to have no tolerance after 40 weeks of regular use.

The rest of the section is a bit verbose and could be redacted.

I don't have time in the next couple of days to do the edit justice, but I'll keep this on my to do list. As usual, feel free to preempt me ;-) D Anthony Patriarche (talk) 17:09, 10 July 2024 (UTC)[reply]

@D A Patriarche thank you, you have made a good observation. I edited the first paragraph to address your concern. Maxim Masiutin (talk) 18:11, 11 October 2024 (UTC)[reply]

State of this article

I don't know about reference bureaucracy in English Wikipedia, but this article now feels like heavy based on critique and make modafinil to sound like as "inferior amphetamine". I would like to remind that is very mild drug in it's psychoactivity, more comparable to caffeine, regardless of drug laws.

Adverse effects like severe allergic reactions is very rare and should be stated as such in introduction. The most common one is headache. While this is abused a lot, there are contradictory research about addiction potential and tolerance to this drug. Even if there is, it's definitely not similar to classic dopamine drugs. Euphoria is more like a rare adverse effect. Probably more people will perceive it as dysphoric from increased anxiety. Also, trying to state stimulant doesn't increase cognitive functioning, is like saying that water isn't wet.

I won't change anything here, just my impression about where this is heading to recent months. --GreenZeb (talk) 07:01, 4 August 2024 (UTC)[reply]

@GreenZeb Better safe than sorry. Maxim Masiutin (talk) 17:59, 11 October 2024 (UTC)[reply]

@GreenZeb I added a clarification that allergic/immunological reactions are rare. Maxim Masiutin (talk) 18:19, 11 October 2024 (UTC)[reply]